# Promethease Report

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ABO blood group predictions are brand new, and still under development. We're rolling it out to you so we can see how it performs on real data. All conclusions are still greatly limited by the general lack of phased data, the lack of genotyping at all of the necessary snps, and other factors.

best guess:

## ABO blood type
O

    rs8176719(D;D)
    rs8176746(C;C)

rs8176719 (D;D) indicates you are type-O
you were not genotyped at either rs590787 nor i4001527 so it is impossible to see your Rh blood type
Are you really type O?
Sorry, an error was occurred while submitting your feedback. Please try again later.

### But the ABO system is quite limited

Blood, you see, doesn't just come in types A, B, AB, and O. The "positive" or "negative?" Nope. In fact, let's get all the way into the weeds: Scientists have since discovered over 300 proteins that contribute to blood type. The AB+ on your blood donor card? Yeah, that's a massive oversimplification... read more at Beyond Blood Type: Genomics Can Show What You're Really Made Of

or

It would be straightforward if we all had the same blood. But we don't. On the surface of every one of our red blood cells, we have up to 342 antigens - molecules capable of triggering the production of specialised proteins called antibodies. It is the presence or absence of particular antigens that determines someone's blood type.

Some 160 of the 342 blood group antigens are 'high-prevalence', which means that they are found on the red blood cells of most people. If you lack an antigen that 99 per cent of people in the world are positive for, then your blood is considered rare. If you lack one that 99.99 per cent of people are positive for, then you have very rare blood.

If a particular high-prevalence antigen is missing from your red blood cells, then you are 'negative' for that blood group. If you receive blood from a 'positive' donor, then your own antibodies may react with the incompatible donor blood cells, triggering a further response from the immune system. These transfusion reactions can be lethal. Read more at The man with the golden blood.

## Known ABO SNPs

23andMe ABO
Index | Gene | SNP | Geno | Repute | Magnitude | Summary
--- | --- | --- | --- | --- | --- | ---
1 |  | rs7466519 | not tested |  |  |
2 |  | rs8176750 | not tested |  |  |
3 |  | rs56202119 | not tested |  |  |
4 |  | i4000505 | not tested |  |  |
5 |  | rs56231718 | not tested |  |  |
6 |  | rs55788852 | not tested |  |  |
7 |  | rs55927860 | not tested |  |  |
8 |  | rs8176749 | not tested |  |  |
9 |  | rs56190619 | not tested |  |  |
10 |  | rs55783488 | not tested |  |  |
11 |  | rs56355240 | not tested |  |  |
12 |  | i4000504 | not tested |  |  |
13 |  | rs56409303 | not tested |  |  |
14 |  | rs55805279 | not tested |  |  |
15 |  | rs56106480 | not tested |  |  |
16 |  | rs8176747 | not tested |  |  |
17 |  | rs41302905 | not tested |  |  |
18 |  | rs8176746 | (C;C) |  | 0 |
19 |  | rs8176745 | not tested |  |  |
20 |  | rs55951833 | not tested |  |  |
21 |  | rs8176743 | not tested |  |  |
22 |  | i5007173 | not tested |  |  |
23 |  | rs55739900 | not tested |  |  |
24 |  | rs56116432 | not tested |  |  |
25 |  | rs56031507 | not tested |  |  |
26 |  | rs8176741 | not tested |  |  |
27 |  | rs56408700 | not tested |  |  |
28 |  | rs8176740 | (A;T) |  |  |
29 |  | rs55827808 | not tested |  |  |
30 |  | rs8176739 | not tested |  |  |
31 |  | rs56223957 | not tested |  |  |
32 |  | rs56189011 | not tested |  |  |
33 |  | rs56089890 | not tested |  |  |
34 |  | rs55727303 | not tested |  |  |
35 |  | rs7853989 | not tested |  |  |
36 |  | rs55964869 | not tested |  |  |
37 |  | rs55756402 | not tested |  |  |
38 |  | i5007171 | not tested |  |  |
39 |  | rs1053878 | not tested |  |  |
40 |  | rs55658842 | not tested |  |  |
41 |  | rs7873522 | not tested |  |  |
42 |  | rs8176732 | not tested |  |  |
43 |  | rs2073824 | not tested |  |  |
44 |  | rs8176722 | (G;G) |  |  |
45 |  | rs8176721 | not tested |  |  |
46 |  | rs8176720 | not tested |  |  |
47 |  | rs8176719 | (D;D) |  |  | likely to be of blood type O
48 |  | rs56231711 | not tested |  |  |
49 |  | rs8176717 | not tested |  |  |
50 |  | rs512770 | not tested |  |  |
51 |  | rs641959 | not tested |  |  |
52 |  | rs514708 | not tested |  |  |
53 |  | rs55958637 | not tested |  |  |
54 |  | rs549446 | not tested |  |  |
55 |  | rs8176704 | (C;C) |  |  |
56 |  | rs574347 | not tested |  |  |
57 |  | rs688976 | not tested |  |  |
58 |  | rs687289 | (C;C) |  |  |
59 |  | rs2073828 | not tested |  |  |
60 |  | rs55876802 | not tested |  |  |
61 |  | rs8176694 | not tested |  |  |
62 |  | rs672316 | not tested |  |  |
63 |  | rs657152 | (G;G) | Good | 0 | common/normal
64 |  | rs8176682 | not tested |  |  |
65 |  | rs474279 | not tested |  |  |
66 |  | rs500498 | not tested |  |  |
67 |  | rs505922 | (T;T) | Good | 2 | blood type O
68 |  | rs507666 | (G;G) |  |  |
69 |  | rs630014 | (T;T) |  |  |

SNPedia ABO
Index | Gene | SNP | Geno | Repute | Magnitude | Summary
--- | --- | --- | --- | --- | --- | ---
1 |  | rs1053878 | not tested |  |  |
2 |  | rs2073824 | not tested |  |  |
3 |  | rs2073828 | not tested |  |  |
4 |  | rs2519093 | not tested |  |  |
5 |  | rs41302905 | not tested |  |  |
6 |  | rs500498 | not tested |  |  |
7 |  | rs505922 | (T;T) | Good | 2 | blood type O
8 |  | rs507666 | (G;G) |  |  |
9 |  | rs512770 | not tested |  |  |
10 |  | rs514659 | (A;A) |  |  |
11 |  | rs55722397 | not tested |  |  |
12 |  | rs55964869 | not tested |  |  |
13 |  | rs56392308 | not tested |  |  |
14 |  | rs574347 | not tested |  |  |
15 |  | rs612169 | not tested |  |  |
16 |  | rs630014 | (T;T) |  |  |
17 |  | rs643434 | not tested |  |  |
18 |  | rs644234 | not tested |  |  |
19 |  | rs657152 | (G;G) | Good | 0 | common/normal
20 |  | rs687289 | (C;C) |  |  |
21 |  | rs687621 | not tested |  |  |
22 |  | rs7853989 | not tested |  |  |
23 |  | rs8176694 | not tested |  |  |
24 |  | rs8176704 | (C;C) |  |  |
25 |  | rs8176719 | (D;D) |  |  | likely to be of blood type O
26 |  | rs8176720 | not tested |  |  |
27 |  | rs8176722 | (G;G) |  |  |
28 |  | rs8176740 | (A;T) |  |  |
29 |  | rs8176741 | not tested |  |  |
30 |  | rs8176743 | not tested |  |  |
31 |  | rs8176746 | (C;C) |  | 0 |
32 |  | rs8176747 | not tested |  |  |
33 |  | rs8176749 | not tested |  |  |
34 |  | rs8176750 | not tested |  |  |

Medicines and Drug Metabolism

Pharma
Index | Gene | SNP | Geno | Repute | Magnitude | Summary
--- | --- | --- | --- | --- | --- | ---
1 |  | rs2231142 | (A;C) | Bad | 2.1 | 1.74x increased gout risk; gefinitib takers 4x more susceptible to diarrhea
2 |  | rs72552713 | (G;G) | Good | 0 | common in complete genomics
3 |  | rs1800497 | (C;C) | Good | 3 | Normal (A2/A2)
4 |  | rs429358 | (T;T) | Good | 0 | common
5 |  | rs7412 | (C;C) | Bad | 1.1 | more likely to gain weight if taking olanzapine
6 |  | rs4680 | (A;A) | Good | 2.5 | (worrier) advantage in memory and attention tasks
7 |  | rs12720461 | (C;C) | Good | 0 | normal
8 |  | rs2069514 | not tested |  |  |
9 |  | rs35694136 | not tested |  |  |
10 |  | rs56107638 | not tested |  |  |
11 |  | rs762551 | (A;A) |  | 1.5 | Faster caffeine metabolism in smokers and heavy coffee consumers
12 |  | rs12721655 | not tested |  |  |
13 |  | rs2279343 | (A;A) | Good | 0 | common in clinvar
14 |  | rs28399499 | (T;T) | Good | 0 | common in complete genomics
15 |  | rs3211371 | not tested |  |  |
16 |  | rs34097093 | (C;C) | Good | 0 | common in complete genomics
17 |  | rs34223104 | (T;T) | Good | 0 | common in complete genomics
18 |  | rs35303484 | not tested |  |  |
19 |  | rs3745274 | not tested |  |  |
20 |  | rs12248560 | (C;T) |  | 2 | CYP2C19*17 ultra fast metabolizer; drug metabolism effects; also 0.77x decreased breast cancer risk
21 |  | rs17878459 | not tested |  |  |
22 |  | rs17884712 | not tested |  |  |
23 |  | rs17885098 | not tested |  |  |
24 |  | rs17886522 | not tested |  |  |
25 |  | rs28399504 | (A;A) | Good | 0 | normal
26 |  | rs3758580 | not tested |  |  |
27 |  | rs41291556 | (T;T) | Good | 0 | normal
28 |  | rs4244285 | (G;G) | Good | 0 | normal
29 |  | rs4986893 | (G;G) | Good | 0 | normal
30 |  | rs55640102 | not tested |  |  |
31 |  | rs56337013 | (C;C) | Good | 0 | normal
32 |  | rs6413438 | (C;C) | Good | 0 | normal
33 |  | rs72552267 | (G;G) | Good | 0 | normal
34 |  | rs72558186 | not tested |  |  |
35 |  | rs1057910 | (A;A) | Good | 0.1 | normal; no effect on warfarin metabolism
36 |  | rs1799853 | (C;C) | Good | 1 | normal; no risk of altered warfarin metabolism or NSAID metabolism
37 |  | rs28371685 | (C;C) | Good | 0 | normal
38 |  | rs28371686 | not tested |  |  |
39 |  | rs56165452 | not tested |  |  |
40 |  | rs72558187 | not tested |  |  |
41 |  | rs72558188 | not tested |  |  |
42 |  | rs72558190 | not tested |  |  |
43 |  | rs7900194 | not tested |  |  |
44 |  | rs7900194 | not tested |  |  |
45 |  | rs9332130 | (A;A) | Good | 0 | normal
46 |  | rs9332131 | (I;I) |  |  | normal
47 |  | rs9332239 | (C;C) | Good | 0 | normal
48 |  | rs1065852 | not tested |  |  |
49 |  | rs1080985 | not tested |  |  |
50 |  | rs147960066 | not tested |  |  |
51 |  | rs16947 | not tested |  |  |
52 |  | rs28371706 | not tested |  |  |
53 |  | rs28371720 | not tested |  |  |
54 |  | rs28371725 | (G;G) | Good | 0 | normal
55 |  | rs35742686 | not tested |  |  |
56 |  | rs3892097 | not tested |  |  |
57 |  | rs5030655 | (I;I) |  |  | normal
58 |  | rs5030862 | (G;G) | Good | 0 | normal
59 |  | rs5030863 | not tested |  |  |
60 |  | rs5030865 | not tested |  |  |
61 |  | rs5030865 | not tested |  |  |
62 |  | rs5030867 | (A;A) | Good | 0 | normal
63 |  | rs59421388 | (C;C) | Good | 0 | common in complete genomics
64 |  | rs72549349 | not tested |  |  |
65 |  | rs72549351 | not tested |  |  |
66 |  | rs72549353 | not tested |  |  |
67 |  | rs72549354 | not tested |  |  |
68 |  | rs72549357 | not tested |  |  |
69 |  | rs769258 | not tested |  |  |
70 |  | rs12721629 | not tested |  |  |
71 |  | rs2740574 | (A;G) |  |  | carrier of one CYP3A4*1B allele
72 |  | rs35599367 | (C;C) | Good | 0 | common in complete genomics
73 |  | rs4646438 | not tested |  |  |
74 |  | rs4986910 | (T;T) | Good | 0 | normal
75 |  | rs4987161 | (T;T) | Good | 0 | normal
76 |  | rs55785340 | (A;A) | Good | 0 | normal
77 |  | rs10264272 | (C;C) | Good | 0 | normal
78 |  | rs15524 | (C;T) |  |  |
79 |  | rs28365083 | (C;C) | Good | 0 | normal
80 |  | rs28383468 | (C;C) | Good | 0 | normal
81 |  | rs28383479 | (G;G) | Good | 0 | normal
82 |  | rs41279854 | (A;A) | Good | 0 | normal
83 |  | rs41303343 | not tested |  |  |
84 |  | rs55817950 | (G;G) | Good | 0 | normal
85 |  | rs55965422 | (A;A) | Good | 0 | common genotype
86 |  | rs776746 | (A;G) |  | 2 | carrier of 1 nonfunctional CYP3A5 allele; drug metabolism affects
87 |  | rs1799963 | not tested |  |  |
88 |  | rs6025 | (G;G) | Good | 0 | normal/common risk of thrombosis
89 |  | rs1801131 | (A;C) | Bad | 2.1 | Possibly impaired folate metabolism
90 |  | rs1801133 | (C;C) | Good | 0 | Common genotype: normal homocysteine levels
91 |  | rs1799971 | (A;A) | Good | 0 | normal
92 |  | rs2306283 | (T;T) | Good | 0 | common in clinvar
93 |  | rs4149056 | (T;T) | Good | 0 | normal
94 |  | rs55737008 | (A;A) | Good | 0 | common genotype
95 |  | rs56061388 | (T;T) | Good | 0 | common genotype
96 |  | rs56101265 | (T;T) | Good | 0 | common genotype
97 |  | rs59502379 | (G;G) | Good | 0 | common genotype
98 |  | rs72559745 | not tested |  |  |
99 |  | rs1902023 | not tested |  |  |
100 |  | rs8050894 | not tested |  |  |
101 |  | rs9923231 | (C;C) | Good | 0 | normal
102 |  | rs9934438 | (G;G) | Good | 0 | common in clinvar

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